HORDB

ID: hor002057
Uniprot ID: Q9NDE7(32-72)
Protein name: Insulin B chain
Gene name: PIN
Organism: Aplysia californica (California sea hare)
Family: Insulin family
Source: animal
Expression: Expressed in the central region of the cerebral ganglia mostly within the F and C clusters.
Disease: NA
Comments: NA
Taxonomy: Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: NFEHSCNGYMRPHPRGLCGEDLHVIISNLCSSLGGNRRFLA
Length: 41(32-72)
Propeptide: MSKFLLQSHSANACLLTLLLTLASNLDISLANFEHSCNGYMRPHPRGLCGEDLHVIISNLCSSLGGNRRFLAKYMVKRDTENVNDKLRGILLNKKEAFSYLTKREASGSITCECCFNQCRIFELAQYCRLPDHFFSRISRTGRSNSGHAQLEDNFS
Signal peptide: MSKFLLQSHSANACLLTLLLTLASNLDISLA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002057_AF2.pdb

hor002057_ESM.pdb

Mass:	528585	Formula:	C195H305N63O57S4
Absent amino acids:	KQTW	Common amino acids:	GL
pI:	8.08	Basic residues:	7
Polar residues:	17	Hydrophobic residues:	11
Hydrophobicity:	-31.22	Boman Index:	-7916
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	76.1
Instability Index:	3789.51	Extinction Coefficient cystines:	1615
Absorbance 280nm:	40.38

PubMed ID: 10479677
Title: Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica.